This is sorta a squeal to my previous post about video games that would translate well into Anime. Also these are the ones suggested by YOU so let me know in the comments what games you want in my next list.
5. The Legend Of Zelda
This one needs no explanation. An epic fantasy with a WELL established fan base already and Nintendo backing it, the production value would be excellent. The only issue would be getting Links voice right as he is a mute protagonist. Also it could focus on Zelda and her story as well which would be refreshing.